Giardiasis Disease

BASICS

DESCRIPTION

Intestinal infection caused by the protozoan parasite, Giardia lamblia. Infection results from ingestion of the cysts that excyst into trophozoites which colonize the small intestine and cause the symptoms. The cycle is continued when the trophozoites encyst in the small intestine and water, food, or hands are contaminated by feces of the infected person. Most infections result from fecal-oral transmission or ingestion of contaminated water, less commonly from contaminated food.

  • System(s) affected: Gastrointestinal
  • Genetics: N/A
  • Incidence/Prevalence in USA: 5% of patients with stools submitted for ova and parasite exams. Overall prevalence is lower and variable.
  • Predominant age: All ages, but most common in early childhood
  • Predominant sex: Slightly more common in males
SIGNS AND SYMPTOMS
  • Approximately 25-50% of infected persons are symptomatic
  • Chronic diarrhea (lasting more than 5-7 days and frequently weeks)
  • Abdominal bloating
  • Flatulence
  • Loose, greasy, foul-smelling stools
  • Weight loss
  • Nausea
  • Lactose intolerance
CAUSES

Protozoan parasite (Giardia lamblia) infection acquired through fecal-oral transmission or ingestion of contaminated water, less commonly from contaminated food

RISK FACTORS
  • Day care centers
  • Male homosexuality
  • Wilderness camping

DIAGNOSIS

LABORATORY
  • Stool for ova and parasites, repeated 3 times if necessary. Cysts are seen in fixed or fresh stools and occasionally, trophozoites are found in fresh diarrheal stools.
  • Fluorescent antibody and ELISA tests of fecal specimens are available

Drugs that may alter lab results: A number of drugs interfere with stool exams
Disorders that may alter lab results: N/A

PATHOLOGICAL FINDINGS
Intestinal biopsy shows flattened, mild lymphocytic infiltration and trophozoites on the surface.
SPECIAL TESTS
String test (Entero-Test). A gelatin capsule on a string is swallowed and left in the duodenum for several hours or overnight.
IMAGING
N/A
DIAGNOSTIC PROCEDURES
Esophagogastroduodenoscopy with biopsy and sample of small intestinal fluid.

TREATMENT

APPROPRIATE HEALTH CARE

Outpatient for mild cases, inpatient if symptoms are severe

GENERAL MEASURES
  • Medical therapy for all infected individuals
  • Fluid replacement if dehydrated
SURGICAL MEASURES

N/A

ACTIVITY

As tolerated

DIET

Good nutrition, low lactose, low fat

PATIENT EDUCATION

Avoidance of risk factors

FOLLOW UP

PREVENTION/AVOIDANCE

Good hand washing when caring for diapered children, water purification when camping

POSSIBLE COMPLICATIONS

Those of malabsorption and weight loss

EXPECTED COURSE AND PROGNOSIS

Untreated giardiasis lasts for weeks. Patients usually (90%) respond to treatment within a few days and most of the non-responders or relapses respond to a second course with the same or a different agent.

MISCELLANEOUS

ASSOCIATED CONDITIONS

Hypogammaglobulinemia and possibly IgA deficiency. The diarrhea is more severe and prolonged in these patients.

AGE-RELATED FACTORS

Pediatric: Most common in early childhood
Geriatric: N/A
Others: N/A

PREGNANCY

Concern for potential teratogenicity of medications. Consult infectious disease specialist or gastroenterologist for symptomatic disease.

OTHER NOTES

G. lamblia is also called G. duodenalis, G. intestinalis

ABBREVIATIONS

N/A

Clinical Investigations

ROLE OF HOMOEOPATHY

Copyright © 2025 Selkey. All Rights Reserved.