Obesity Disease

DESCRIPTION
A condition of increased body weight (consisting of both lean and fat tissue) that leads to increased morbidity and mortality. Also defined as weight 20% greater than an individual's desirable weight as defined by the Metropolitan Life Insurance Company or BMI > 28.
  • Android obesity (male pattern or abdominal obesity) is higher risk and gynecoid obesity (female pattern or gluteal obesity) is lower risk for long-term health problems.
  • Obesity threshold (BMI=28)
    Height Weight (lb)
    5' 0" 143
    5' 2" 153
    5' 4" 163
    5' 6" 173
    5' 8" 184
    5' 10" 195
    6' 0" 206
    6' 2" 218
    6' 4" 230
  • System(s) affected: Gastrointestinal, Endocrine/Metabolic
  • Genetics: 25-30% of the variance in body fat is genetically transmitted
  • Incidence/Prevalence in USA:
    • Ages 35-44: 1600/100,000 males; 1400/100,000 females
    • Ages 65-74: 500/100,000 males; 400/100,000 females
    • 20-30% of adult men and 30-40% of adult women (according to an NIH panel)
  • Predominant age: All ages
  • Predominant sex: Female > Male
SIGNS AND SYMPTOMS
Increased body weight and adipose tissue
CAUSES
  • Multifactorial
  • Rare genetic syndromes have been described
  • Idiopathic obesity is assumed to be due to an imbalance between food intake and energy expenditure (physical activity and metabolic rate)
  • Insulinoma
  • Hypothalamic disorders
  • Cushing's syndrome
  • Corticosteroid drugs
RISK FACTORS
  • Parental obesity
  • Pregnancy
  • Sedentary lifestyle
  • High fat diet
  • Low socioeconomic status
LABORATORY
  • Not needed for diagnosis
  • Consider thyroid function tests
  • Cardiac risk factors: serum cholesterol, triglycerides, glucose

Drugs that may alter lab results: N/A
Disorders that may alter lab results: Hypothyroidism

PATHOLOGICAL FINDINGS
  • Hypertrophy and/or hyperplasia of adipocytes
  • Cardiomegaly
  • Hepatomegaly
SPECIAL TESTS
  • Body mass index (BMI) = body weight (kg) divided by the square of body height (m). Obesity is BMI > 28 kg/m².
  • Determine fat distribution pattern by measuring waist and hips circumferences and calculating the waist to hips ratio (WHR)
  • Android (male pattern, or abdominal obesity) has WHR greater than 0.85 for females; 0.95 for males
  • Gynecoid (female pattern, or gluteal obesity) has WHR less than 0.85 for females; 0.95 for males
IMAGING
N/A
DIAGNOSTIC PROCEDURES
N/A
APPROPRIATE HEALTH CARE

Outpatient

GENERAL MEASURES
  • Appropriate functions for the primary care physician include: assessment of degree of health risk from BMI and WHR (see Diagnosis); assessment of motivation to lose weight; helping patients to set goals of therapy; office counseling or referral to a registered dietitian or weight loss program for in-depth counseling on diet, exercise, and behavior modification; long term follow-up
  • Many reputable commercial and community programs exist for obesity treatment. Desirable programs should include diets which meet the RDA for nutrients, exercise counseling, behavior modification, and provision for long term maintenance. Physicians can provide valuable additional monitoring and long term follow-up.
SURGICAL MEASURES

Occasionally, treat patients with severe obesity (BMI > 40 kg/m2) with a gastric bypass or stapling procedure. This involves complex pre-surgical evaluation, surgery and followup and should be done in a center skilled in this treatment. Surgical treatment is the most effective long term weight loss treatment available for morbid obesity.

ACTIVITY
  • Exercise alone rarely causes significant weight loss, but may improve long term results of weight loss treatment and should be an integral part of any weight loss program.
  • Exercise regimens involve 30 minutes 3-5 times/week. Increasing calories expended in activities throughout the day is also important.
  • Many patients benefit from an "exercise prescription"
DIET
  • Diet restriction is the cornerstone of obesity management (low-fat, high-complex carbohydrate and high-fiber)
  • A 500 kcal (2.10 MJ) reduction in calorie per day intake will result in approximately 1 pound (0.45 kg) weight loss per week
  • Very low calorie diets (VLCD)
    • 400-800 kcal (1.68-3.35 MJ) per day are usually based on liquid formulas and cause more rapid weight loss
    • Complications of VLCD include: dehydration, orthostatic hypotension, fatigue, muscle cramps, constipation, headache, cold intolerance, and relapse after discontinuation
    • Contraindications of VLCD include: recent myocardial infarction or cerebrovascular accident, renal or hepatic disease, cancer, pregnancy, insulin-dependent diabetes mellitus, some psychiatric disturbances
    • Physician supervision is important for VLCD
PATIENT EDUCATION
  • Educating the patient about the value of weight reduction is important
  • Behavior modification can improve dietary adherence and long term results of weight loss and should be included in any weight loss program
  • A self help brochure "On Your Way to Fitness" can be ordered for $1.00 per copy from Shape Up America, P.O. Box 9738, Bridgeport, CT 06699. It gives information for exercise self-assessment and increasing exercise for obese patients. Patients can also visit the website www.shapeup.org.
PREVENTION/AVOIDANCE

Counseling in regular exercise and prudent diet with regular follow-up, especially in children and young adults and those with family history of obesity or diabetes mellitus

POSSIBLE COMPLICATIONS
  • Increased mortality due largely to cardiovascular disease
  • Diabetes mellitus
  • Hypertension
  • Hyperlipidemia
  • Gall bladder disease with cholelithiasis
  • Osteoarthritis
  • Gout
  • Thromboembolism
  • Hypoventilation and sleep apnea syndromes
  • Poor self-esteem
  • Occupational discrimination
EXPECTED COURSE AND PROGNOSIS
  • Long term maintenance of weight loss is extremely difficult
  • If patient is not motivated, successful weight loss is unlikely
ASSOCIATED CONDITIONS

See Possible complications

AGE-RELATED FACTORS

Pediatric: Prevalence of obesity is increasing. Among other factors, decreased physical activity and increased television viewing have been implicated.
Geriatric: Desirable weights (those associated with the lowest risk of mortality) increase with age
Others: Pre-puberty and young adulthood appear to be sensitive periods for development of obesity

PREGNANCY

Pregnancy is a common time for onset of, or increase in obesity

OTHER NOTES

N/A

ABBREVIATIONS

RDA = recommended daily allowance
BMI = body mass index

Clinical Investigations

ROLE OF HOMOEOPATHY

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